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Effects of different anesthesia methods on the circadian rhythm of melatonin in elderly patients and its correlation with postoperative delirium

Effects of different anesthesia methods on the circadian rhythm of melatonin in elderly patients and its correlation with postoperative delirium

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1800016304
Enrollment
Unknown
Registered
2018-05-24
Start date
2018-06-01
Completion date
Unknown
Last updated
2018-05-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anesthesia of total hip arthroplasty

Interventions

Group RA:intraspinal anesthesia
Group GA:general anesthesia

Sponsors

Department of Anesthesiology, Peking University Third Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
65 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients with American Society of Anesthesiologists (ASA) I or III, scheduled for total hip arthroplasty under anesthesia,all genders, aged years =65,total time more than 2 hours, will be prospectively studied.

Exclusion criteria

Exclusion criteria: Patients with severe diseases, including uncontrolled hypertension and/or diabetes mellitus, severe heart and cerebrovascular diseases, and refused to sign an informed consent form, will be excluded.

Design outcomes

Primary

MeasureTime frame
Blood melatonin concentration ;Urine melatonin concentration;Recovery profile;mental state examination;Delirium Rating;—

Secondary

MeasureTime frame
Hemodynamic changes;blood gas analysis;Adverse effect;Ramsay;Mild cognitive impairment;Depression scale assessment;—

Countries

China

Contacts

Public ContactZhengqian Li

Department of Anesthesiology, Peking University Third Hospital

lizhengqianmazui@126.com18001298582

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026