nonalcoholic steatohepatitis
Conditions
Interventions
Case series:Diet
Sponsors
Affiliated Hospital of Hangzhou Normal University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Male and female aged 18 to 75 years old; 2. BMI 1.5ULN or liver biopsy confirmed as NASH; 4. Patients taking antihypertensive medications require blood pressure to be stable with stable daily doses of antihypertensive medication within 2 months prior to enrollment. <140/90mmHg); During the clinical trial, patients can continue to take antihypertensive drugs; 5. Patients taking statin/fibrate lipid-lowering drugs, requiring a stable daily dose within 3 months before enrollment, in clinical During the trial, patients can continue to take lipid-lowering drugs; 6. did not receive the following drugs within 3 months before enrollment (metformin, thiazolidinedione hypoglycaemic agents, DPP-4 inhibitors, GLP-1, SGLT2 inhibitors, polyene phosphatidylcholine, glycyrrhizic acid preparation, bicyclol, reduced glutathione, S-adenosylmethionine, silymarine, OCA/UDCA, betaine, fish oil, phosphodiesterase inhibitor, Kyrgyzstan Non-rozzies, probiotics and long-term antibiotics for more than 1 week); 7. Understand this study and signed informed consent.
Exclusion criteria
Exclusion criteria: 1. in the past 5 years, alcohol and/or drug abuse and dependence; 2. female average daily alcohol intake >10g/days, male average daily alcohol intake >20g/days; 3. combined with other acute and chronic active liver disease (viral hepatitis, hereditary scarlet disease, hepatolenticular degeneration, ?-resistance to trypsin deficiency, alcoholic liver disease, drug-related liver disease); 4. cirrhosis patients; 5. The Heart function is not complete, the heart function grade is 2, 3 or 4; 6. with heart pacemaker patients; 7. uncontrolled hypertension; 8. renal insufficiency, blood creatinine > normal upper limit; 9. pregnant or lactating women; 10. female early Pregnancy screening test positive, or the observation period does not want to contraceptive person; 11. The combination of HIV infection; 12. cannot accept MRI examination; 13. Long-term use of antibiotics (> 1 weeks); 14. uncontrolled hypothyroidism (upper limit of normal tsh>2 times); 15. Other researchers do not think that the completion of clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| glutamic-pyruvic transaminase;glutamic oxalacetic transaminase;gamma-glutamyltransferase;alkaline phosphatase;MRI-PDFF; | — |
Countries
China
Contacts
Public ContactJunping Shi
Affiliated Hospital of Hangzhou Normal University
Outcome results
None listed