Immune thrombocytopenic purpura
Conditions
Interventions
experimental group:danazol combined with low-dose glucocorticoids
Sponsors
Second Affiliated Hospital of Dalian Medical University
Eligibility
Sex/Gender
Female
Age
40 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. voluntarily signing the informed consent form and being able to comply with the research scheme; 2. meet the diagnostic criteria of refractory primary ITP; (1) platelet count was less than 30 x 10^9 / l for two consecutive times ( not within the same day ); (2) ineffective or recurrent splenectomy and hormone dependence or ineffective recurrence; (3) treatment is needed to reduce the risk of bleeding; (4) except other secondary thrombocytopenia. 3. there is no definite upper limit for postmenopausal women; 4. There is no obvious dysfunction such as heart, lung, liver and kidney, and uncontrollable hypertension and diabetes.
Exclusion criteria
Exclusion criteria: 1. secondary thrombocytopenia; 2. complicated with serious heart-lung and liver-kidney diseases; 3. specific allergic constitution and intolerance to therapeutic drugs; 4. previous history of thrombosis; 5. merger of neoplastic diseases; 6. patients with severe osteoporosis; 7. patients with mental history; 8. suspected or did have a history of alcohol and drug abuse; 9. serious or uncontrollable infection; 10. participants in other clinical trials in recent 4 weeks; 11. cannot be followed up regularly.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the number of platelets; | — |
Countries
China
Contacts
Public ContactYan Jinsong
Second Affiliated Hospital of Dalian Medical University
Outcome results
None listed