postoperative pulmonary complications
Conditions
Interventions
B:normal saline
Sponsors
Peking University Third Hospital
Eligibility
Sex/Gender
All
Age
51 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) To be scheduled for oral and maxillofacial surgery with fibular free flap reconstruction that was expected to exceed 3 hours under general anesthesia; (2) Aged 51 years old or over; (3) took tracheotomy before the end of the surgery; (4) had an intermediate to high risk of developing PPCs judged by Assess Respiratory Risk in Surgical Patients in Catalonia (ARISCAT) score(cumulative ARISCAT risk score were 26 or greater).
Exclusion criteria
Exclusion criteria: (1) body mass index of 35 or higher; (2) allergic to DEX; (3) recent sedatives-taking history; (4) sick sinus syndrome, or severe sinus bradycardia(<50 beats per min[bpm]), or second degree or greater atrioventricular block without pacemaker; (5) previous lung surgery history, or severe chest wall malformation, or acute exacerbation of chronic obstructive pulmonary disease (AECOPD), or uncontrolled asthma (Asthma control test = 18), or pulmonary artery stenosis, or pulmonary hypertension; (6) complex heart deformities, congestive heart failure, or known preoperative left ventricular ejection fraction less than 30%; (7) serious hepatic dysfunction(Child-Pugh class C), or serious renal dysfunction(requirement of renal replacement therapy); (8) a history of mental illness; (9) refused to participate in the clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| postoperative pulmonary complications; | — |
Countries
China
Contacts
Public ContactYun Liu
Peking University Hospital of Stomatology
Outcome results
None listed