Gastric cancer
Conditions
Interventions
Case series:aptinib+S-1+ oxaliplatin
Sponsors
Yantai Yuhuangding Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18~75 years old; 2. ECOG(Eastern Cooperative Oncology Group) 0~1; 3. Definitely diagnosed gastric adenocarcinoma through Pathology or Cytology with Her2-negative; 4. Expected lifetime acuity =3 months; 5. Without the history of anti-tumor therapy including Radiotherapy, chemotherapy, targeted therapy, immunotherapy 6. Normal hemodynamic indices before the recruitment(including blood cell count and liver/kidney function ). For example: WBC>4.0×10^9/L, NE>1.5×10^9/L, PLT>100×10^9/L, BIL50ml/min using Cockcroft-Gault formula,and Cr=1×ULN; 8. Good cardiac function before the recruitment, no seizure of myocardial infarction in past half years, and controllable hypertension and other coronary heart disease; 9. Not concomitant with other uncontrollable benign disease before the recruitment (e.g. the infection in the kidney, lung and liver); 10. Signed the Informed Consent Form.
Exclusion criteria
Exclusion criteria: 1. Distal metastasis to lung, brain, and bone but liver 2. Her-2 test was positive and willing to receive Hessaitin treatment 3. Operation intolerance due to other uncontrolled diseases(Including atrial fibrillation, angina pectoris, cardiac dysfunction, ejection fraction less than 50%, refractory hypertension, and renal dysfunction) 4. Ever administrated with other drugs(including TCM drugs) before the recruitment, or no guarantee of progress according to the study requirement after recruitment 5. Allergy to the drugs in this protocol 6. Pregnant and lactating women 7. Women at childbearing age and of pregnancy desire during the study 8. Any medical or other condition that in the opinion of the investigator would preclude the subjects participation in a clinical study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| radical resection rate;safety; | — |
Secondary
| Measure | Time frame |
|---|---|
| DCR;ORR; | — |
Countries
China
Contacts
Public ContactJiang Lixin
Yantai Yuhuangding Hospital
Outcome results
None listed