H-type hypertension
Conditions
Interventions
Twelve: Folic acid supplementation
Sponsors
Medical University Of Anhui
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) adults over 18 years old; (2) baseline blood pressure met the following criteria: 90mmHg = <110mmHg and / or 140mmHg. Shrinkage pressure <180mmHg; (3) blood homocysteine was more than 10 mol/L; (4) clinicians judged that Folic Acid Tablets was suitable for enalapril treatment; (5) voluntarily participating in and signing informed consent; If subjects did not regularly take antihypertensive drugs, they could be directly included in the study. If the subjects had regular ACEI antihypertensive drugs, enalapril could be included in the study if the subjects were voluntarily changed. If the subjects have been regularly taking non ACEI antihypertensive drugs, the replacement of the antihypertensive drugs to enalapril and tolerable can be included in the study under the voluntary premise of the subjects.
Exclusion criteria
Exclusion criteria: (1) serious mental disorders, unable to express their wishes; (2) there are obvious other abnormal signs, laboratory tests and clinical diseases, according to the researchers' findings; It is not suitable to participate in the researchers; (3) other clinicians judged that it was not suitable to use enalapril Folic Acid Tablets; (4) other researchers judged that the long-term follow-up could not be completed; (5) the history of cerebral apoplexy, coronary heart disease, congenital heart disease, severe stenosis of intracranial and extracranial vessels, cardiac insufficiency, acute / chronic renal insufficiency, long term use of Folic Acid Tablets and the inability to tolerate ACEI antihypertensive drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Plasma homocysteine level;Folic acid level;MTHFR genotypes; | — |
Countries
China
Contacts
Public ContactTang Genfu
School of Health Management, Anhui Medical University
Outcome results
None listed