hemophagocytic lymphohistiocytosis
Conditions
Interventions
Case series:DEP-Ru regimen
Sponsors
Beijing Friendship Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
1 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. meet HLH-04 diagnostic criteria; 2. treated with HLH-94 no less than 2 weeks before enrollment and did not achieve at least PR; or relapsed patients after remission; 3. Life expectancy exceeds 1 month; 4. Aged 1 year old to 70 years old male and female; 5. Before the start of the study, total bilirubin = 10 times the upper limit of normal; serum creatinine = 1.5 times normal; 6. Serum HIV antigen or antibody negative; 7. HCV antibody is negative, or HCV antibody is positive, but HCV RNA is negative; 8. Both HBV surface antigen and HBV core antibody were negative. If any of the above is positive, peripheral blood hepatitis B virus DNA titer should be detected, and less than 1×103 copies/ml can enter the group; 9. Echocardiographic examination of LVEF = 50%; 10. Informed consent.
Exclusion criteria
Exclusion criteria: 1. Heart function above grade II (NYHA); 2. Accumulated dose of doxorubicin above 300mg/m2 or epirubicin above 450mg/m2; 3. Pregnancy or lactating Women; 4. Allergic to Pegaspargase, doxorubicin or etoposide; 5. Active bleeding of the internal organs; 6. uncontrollable infection; 7. Serious mental illness; 8. Non-melanoma skin cancer history; 9. Patients unable to comply during the trial and/or follow-up phase; 10. Participate in other clinical research at the same time.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| sCD25;neutrophil;hemoglobin;thrombocyte;ferritin;triglyceride;glutamic-pyruvic transaminase;Hemophagocytosis;NK activity;Fibrinogen;Total bilirubin; | — |
Countries
China
Contacts
Public ContactWang Zhao
Beijing Friendship Hospital, Capital Medical University
Outcome results
None listed