Hypertensive heart disease
Conditions
Interventions
test group:Daily oral resveratrol 400mg
Control group:nothing
Sponsors
Qilu Hospital of Shandong University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged >= 18 years, male or female, signing informed consent; 2. According to the WHO-ISH "Guide to Hypertension Treatment", hypertension inclusion criteria: (1) In the absence of antihypertensive drugs, systolic blood pressure >=140 mmHg and/or diastolic blood pressure >= 90 mmHg measured on the 3rd day of the same day may be diagnosed as hypertension. The patient has a history of hypertension and is currently taking antihypertensive drugs. Although the blood pressure is lower than 140/90 mmHg, he is still diagnosed with hypertension; (2) Family self-test blood pressure >= 135/85mmHg; (3) 24-h ambulatory blood pressure daytime average >= 135/85mmHg, or 24h average >= 130/80mmHg; 3. According to the Expert Consensus on Diagnosis and Treatment of Hypertension Complicated with Left Ventricular Hypertrophy in Asia, Hypertension combined with myocardial hypertrophy was included in the criteria: (1) diagnosis of hypertension; (2) The electrocardiogram satisfies SV1 + RV5> 3.5 mV or cornell voltage-time product> 244 mV.ms; (3) Echocardiography satisfies LVMI >= 115g/m2 (male), >= 95g/m2 (female), or interventricular septal thickness (IVST)/left ventricular posterior wall thickness (LVPWT) >= 11 mm (male), >=10 mm (female).
Exclusion criteria
Exclusion criteria: (1) hypertrophic cardiomyopathy or other causes of cardiac hypertrophy in addition to hypertension; clear secondary hypertension (such as aortic coarctation, pheochromocytoma, renovascular hypertension or renal parenchymal hypertension) patient; (2) 3 months of history of stroke, cardiomyopathy, valvular disease and congenital heart disease, patients with new complete left bundle branch block or severe malignant arrhythmia; (3) difficult to control high blood pressure / hypotension: systolic blood pressure >= 200mmHg or diastolic blood pressure >= 110mmHg; or systolic blood pressure <= 90mmHg or diastolic blood pressure <= 60mmHg; (4) Severe liver and kidney dysfunction; (5) At the judgement of the investigator, previous or current diseases may affect the patient's participation in the trial or affect the outcome of the study, such as: malignant diseases, autoimmune diseases, severe liver and kidney diseases, hematological diseases, and coagulative diseases; (6) Patients who participated in other clinical investigators within 3 months of pregnancy, breast-feeding or have a pregnancy plan; (7) Other investigators consider it inappropriate to participate in the study (such as cognitive impairment or self-care).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Left ventricular mass index;Myocardial remodeling;Degree of myocardial fibrosis; | — |
Secondary
| Measure | Time frame |
|---|---|
| Left ventricular diastolic function; | — |
Countries
China
Contacts
Public ContactBu Peili
Qilu Hospital of Shandong University
Outcome results
None listed