ovarian cancer
Conditions
Interventions
Case series:apatinib
Sponsors
First Affiliated Hospital of Harbin Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Women older than eighteen and sign ICF; 2. ECOG 0-2; 3. Estimated survival time=3 mouths; 4. Ovarian epithelial carcinoma diagnosed by pathology or histology; 5. The time of last chemotherapy is more than 4 weeks; 6. The damage caused by other treatments was restored,the interval between nitroso or mitomycin is more than 6 weeks; 7. Other cytotoxic drugs, radiotherapy or surgery were accepted for more than 4 weeks, and the wounds healed completely; 8. The main organs (liver, kidney and heart) function basically normal.
Exclusion criteria
Exclusion criteria: 1. Pregnant or lactating women; 2. High blood pressure and failure to be reduced to normal range by antihypertensive drugs(Systolic pressure > 140 mmHg, diastolic pressure >90mmHg); 3. Variety of factors affecting oral drugs (such as inability to swallow, chronic diarrhea, and intestinal obstruction); 4. Coagulopathy (INR>1.5×ULN APTT>1.5×ULN), with Bleeding tendency; 5. Urinary protein is more than + + and confirmed the 24 hour urinary protein quantitative>1g; 6. Received apatinib or other VEGFR inhibitors, such as bevacizumab, Solafinib, Sunitinib; 7. Metastases of the central nervous system with symptoms; 8. Other cases the researchers judged that could affect the outcome of the clinical study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ORR; | — |
Secondary
| Measure | Time frame |
|---|---|
| PFS;OS; | — |
Countries
China
Contacts
Public ContactZhiping Liu
First Affiliated Hospital of Harbin Medical University
Outcome results
None listed