PREQUEL (PREhabilitation for improving QUality of recovery after ELective cardiac surgery) Study: a randomised controlled trial

Conditions

Patients undergoing elective cardiac surgery (CABG, with/without valvular interventions) Pre-frail and Frail patients

Yau DKW, Ng FF, Wong MH, Underwood MJ, Wong RHL, Joynt GM, Lee A.

2024-11-077 citations

10.1016/j.bja.2024.08.039

Multidisciplinary prehabilitation to improve frailty and functional capacity in high-risk elective surgical patients: a retrospective pilot study.

Wong HMK, Qi D, Ma BHM, Hou PY, Kwong CKW, Lee A, Prehab Study Group.

2024-01-238 citations

10.1186/s13741-024-00359-x

PREhabilitation for improving QUality of recovery after ELective cardiac surgery (PREQUEL) study: protocol of a randomised controlled trial.

Derek King Wai Yau, Man Kin Henry Wong, Wai‐Tat Wong, Tony Gin, Malcolm J. Underwood et al. (7 authors)

PubMed2019-05-1434 citations

10.1136/bmjopen-2018-027974

Interventions

Two groups:Exercise training and education 60 minutes per session, twice per week for 6-10 weeks versus Current usual care without prehabilitation program

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Adults undergoing elective primary isolated coronary artery bypass grafting, aortic valve repair/replacement, mitral valve repair/replacement, or combined coronary artery bypass/valve procedures; 2. Prefrail to moderately frail patients with a Clinical Frailty Score of 4-6 at the time of accepting surgery at the outpatient cardiothoracic surgical clinic; 3. Patients with an estimated 8 or more weeks of surgical waiting list time; 4. Agreement on the suitability of the patient for prehabilitation with the attending cardiothoracic surgeon.

Exclusion criteria

Exclusion criteria: 1. Patients with unstable or recently unstable cardiac syndrome (New York Heart Association Class IV, critical left main coronary disease, hospitalization for arrhythmias, congestive heart failure or acute coronary syndrome before randomisation); 2. Patients with severe left ventricular obstructive disease (severe aortic or mitral stenosis, dynamic left ventricular outflow obstruction); 3. Redo cardiac surgery; 4. Contraindications for prehabilitation (those with cognitive deficits unable to comply with study procedures, physical limitations precluding rehabilitation and inability to regularly attend outpatient prehabilitation sessions).

Design outcomes

Primary

Measure	Time frame
Quality of Recovery (QoR);Disability-free survival;	—

Secondary

Measure	Time frame
Major adverse cardiac and cerebrovascular events (MACCE) during hospital;Psychological distress;Health-related quality of life;Costs;	—

Countries

China

Contacts

Public ContactDerek King Wai YAU

Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong

derekyaukw@link.cuhk.edu.hk+852 35051912

Outcome results

None listed