Tumor malnutrition
Conditions
Interventions
test group:Individually formulated enteral nutrition solution
Control group:Standardized enteral nutrition solution
Sponsors
Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Mediccal School
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Subjects diagnosed with malignant tumors by clinical symptoms, imaging examinations, and pathological examinations before surgery; 2.For patients undergoing concurrent chemoradiotherapy, toxic side effects assessment requires a liquid diet or a field test to evaluate subjects who need tube feeding nutrition; 3.Absolute neutrophil counts (fractional nucleus and ribbon nucleus) =1.5×109/L, platelets =100×10^9/L, hemoglobin =9 g/dL; 4.After nutrition risk screening (NRS2002), NRS2002 =3 points; 5.After the nutritional status assessment(PG-SGA)PG-SGA=2 points; 6.Life expectancy> 3 months; 7.Bilirubin, alkaline phosphatase, aspartate aminotransferase, and alanine aminotransferase = 1.5 times the normal upper limit (ULN); 8.Aged 18-75 , all genders; 9.Subjects are conscious, have no communication problems and can answer the question; 10.Agree to participate in this clinical trial and voluntarily sign informed consent.
Exclusion criteria
Exclusion criteria: 1.Head or neck surgery or previous head and neck radiotherapy; 2.Patients with distant tumor metastases; 3.Subjects had or had previous history of other cancers; 4.Subjects with active bacterial, viral or fungal infections (>= Level 2 of NCI-CTC, 3rd Edition); 5.Severe malnutrition, albumin <30g/L; 6.Gastrointestinal tract accompanied by diseases with abnormal digestion and absorption; 7.Use other specially formulated foods or medicines; 8.Thyroid dysfunction; 9.There are serious heart, lung and brain diseases, etc. 10.There are difficult to control diabetes, or other metabolic diseases; 11.With chronic hepatitis, cirrhosis, chronic nephritis, renal insufficiency, etc. 12.Subjects with contraindications to enteral nutrition; 13.Subjects with allergic or intolerable enteral nutrition; 14.Alcoholism or drug addiction; 15.Pregnancy or breastfeeding, or women of childbearing age refuse to use contraception; 16.Researchers consider it inappropriate to participate in this experiment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Albumin;RTOG scale;????CD3+, CD4+, CD8+; | — |
Secondary
| Measure | Time frame |
|---|---|
| Body weight;QLICP-HN (V1.0) scale;Medical expenses; | — |
Countries
China
Contacts
Public ContactYan Jing
Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Mediccal School
Outcome results
None listed