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A randomized controlled trial for effect of antiviral therapy to postoperative recurrence and metastasis of HBV-related HCC in patient with negative HBV-DNA

A randomized controlled trial for effect of antiviral therapy to postoperative recurrence and metastasis of HBV-related HCC in patient with negative HBV-DNA

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1800016069
Enrollment
Unknown
Registered
2018-05-09
Start date
2018-06-01
Completion date
Unknown
Last updated
2018-05-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

hepatocellular carcinoma

Interventions

1:entecavir
2:Without antiviral therapy

Sponsors

The 3rd Affiliated Hospital of Sun Yat-Sen University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. patient receives hepatectomy of HCC, which was confirmed with pathology; 2. serum HBsAg(+)is confirmed preoperatively; 3. serum HBV-DNA is lower than minimum of detection; 4. tumor did not invade potal vein,hepatic vein or major branch of biliary tract; 5. liver function with Child-Pugh A or B; 6. aged from 18-65 years male or female; 7. single tumor=5cm.for multiple tumors,number of tumor=3 and every tumor=3cm.

Exclusion criteria

Exclusion criteria: 1. HCC with metastasis out of the liver; 2. antiviral therapy to HBV within one year; 3. with other malignancy or organ failure; 4. combined with other hepatic virus infection; 5. recieved TACE or other antitumor therapy; 6. liver function with Child-Pugh C; 7. refractory Ascites or hepatic encephalopathy; 8. patient who can not cooperate due to mental diseases or other reasons.

Design outcomes

Primary

MeasureTime frame
tumor recurrence;

Secondary

MeasureTime frame
tumor metastasis;

Countries

China

Contacts

Public ContactRuiyun Xu

The 3rd Affiliated Hospital of Sun Yat-Sen University

1798010960@qq.com+86 13809775140

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026