The Effects of Dexmedetomidine on Postoperative Agitation and Plasma NGAL and Melatonin Concentrations in Patients with Abdominal Surgery.

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR1800016059

Enrollment

Unknown

Registered

2018-05-09

Start date

2018-05-01

Completion date

Unknown

Last updated

2018-05-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

postoperative agitation

Interventions

1:Dexmedetomidin 0.5ug/kg/h

2:Dexmedetomidin 1ug/kg/h

3:0.9 NS

Eligibility

Sex/Gender

All

Age

55 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients with abdominal surgery, ASA I-III, aged 65-75 years, weight 45kg-80kg, no serious history of heart and lung disease, no history of mental disorders before surgery.

Exclusion criteria

Exclusion criteria: Preoperative have serious heart, brain, liver, kidney and other important organ dysfunction, preoperative depression self rating scale (SAS) > 53 points, there is a history of mental illness, long-term application of opioid drugs, other painkillers and history of psychiatric drugs, intraoperative by intraperitoneal adhesion resectable tumors extensively, and palliative surgery, perioperative severe adverse reactions (difficult airway, allergic reactions, bleeding) and postoperative need to send to the intensive care unit.

Design outcomes

Primary

Measure	Time frame
postoperative agitation;	—

Secondary

Measure	Time frame
Melatonin Concentrations;Melatonin Concentrations;	—

Countries

China

Contacts

Public ContactYongtao Gao

Affiliated Hospital of Nantong University

gyt19700114@sina.com+86 13962988003

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026