lung cancer
Conditions
Interventions
Experience group:thoracic paravertebral block + propofol general anesthesia
Control group:opioid + sevoflurane general anesthesia
Sponsors
Third Affiliated Hospital of Army Medical University (Field Surgery Institute)
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Man or female, Aged 40 to 80 years, NYHA grade I-II, ASA grade I-III; 2. Patients with stage I, II, and IIIA non-small cell lung cancer in video-assisted radical resection surgery; 3. Information Consent Signed.
Exclusion criteria
Exclusion criteria: 1. Cortisone and immunosuppressive therapy, received previous neoadjuvant treatments (chemo, hormone, and radiotherapy); 2. History of allergy to local anesthetics; 3. Contraindications to paravertebral block (coagulopathy, infection); 4. Acute infections, severe arrhythmia, mental disease, drug or alcohol abuse; 5. Pregnant, lactation; 6. Enrolled in other trials in 3 months; 7. Any obstacles of follow-up or compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pain score;opioid consumption;the number ofCD4+/CD8+ T and PD-1;VEGF;MMP-2; | — |
Secondary
| Measure | Time frame |
|---|---|
| intraoperative hemodynamic responses;Postoperative nausea and vomiting;sedation-agitation scale; | — |
Countries
China
Contacts
Public ContactChen Liyong
Third Affiliated Hospital of Army Medical University (Field Surgery Institute)
Outcome results
None listed