Liver failure
Conditions
Interventions
Treatment group:Standard of care plus ZhJ-III hybrid bioartificial liver
Control group:Standard of care plus DPMAS
Sponsors
Zhujiang Hospital of Southern Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18~55 years old, all genders; 2. Early or middle stage of sub-acute and chronic on acute liver failure patients caused by HBV; 3. TBil =171umol/L or TBil daily increase more than 17.1 umol/L; 4. PTA between 20% to 50% or INR between 1.5 to 2.6; 5. Without hepatic encephalopathy or less than grade II (grade II included); 6. Patient who is able to understand and sign informed consent, communicate and cooperate with researchers to execute the study.
Exclusion criteria
Exclusion criteria: 1. Primary hepatic carcinoma or metastatic liver cancer; 2. Serious active hemorrhage or disseminated intravascular coagulation; 3. Highly allergic to plasma, heparin or protamine; 4. Circulatory failure; 5. MELD>30; 6. Any uncontrolled clinically significant primary cardiac, pulmonary, vascular, autoimmune diseases or severe diabetes; 7. Any other severe active physical or mental diseases that might affect the treatment, evaluation or compliance on the discretion of the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CLIF-SOFA; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cure rate;CLIF-SOFA;Survival rate;Biochemical indicator;Coagulation function;Inflammatory factors;Endotoxin; | — |
Countries
China
Contacts
Public ContactGAO YI
Zhujiang Hospital of Southern Medical University
Outcome results
None listed