Primary Nephrotic Syndrome
Conditions
Interventions
Case series:NA
Sponsors
Children's Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
No minimum to 18 Years
Inclusion criteria
Inclusion criteria: 1) children with refractory nephrotic syndrome with obvious family history of heredity, primary nephrotic syndrome diagnostic criteria: massive proteinuria: 24h proteinuria or morning urine protein / creatinine (mg/mg) more than 2.0,1 weeks 3 morning urine protein qualitative (+ + + + + +); hypoalbuminemia: serum albumin lower than 25g/L; hyperlipidemia: Serum gallbladder Sterol is higher than 5.7mmol/L; edema in varying degrees. In the above 4 items, 1 and 2 are the necessary conditions for the diagnosis. Hormone sensitive NS: pretreated with prednisone with 2mg/ (kg.d) or 60mg/ (m2.d) for 4 weeks. Hormone resistant NS: with prednisone full treatment for more than 4 weeks of urinary protein still positive, it is divided into primary and late drug resistance, the latter refers to hormone therapy for more than 4 weeks after 1 or multiple remission. Hormone dependent NS: hormone sensitive, but two times reduction or withdrawal within 2 weeks; 2) the negative result of gene detection for renal related diseases.
Exclusion criteria
Exclusion criteria: Elimination of chronic kidney disease caused by secondary factors such as purpura, lupus, hepatitis B and diabetes mellitus.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| whole exome sequencing; | — |
Countries
China
Contacts
Public ContactQiu Li
Children's Hospital of Chongqing Medical University
Outcome results
None listed