Newly diagnose etiology positive pulmonary tuberculosis
Conditions
Interventions
experimental group:Faropenem-based Regimen
control group:Standardized Regimen
Sponsors
Zhejiang University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Newly diagnosed and untreated pulmonary tuberculosis patients with etiology positive pulmonary tuberculosis; 2. Aged between 18 and 80 years; 3. Positive results on sputum smears on two occasions; 4. Sputum was confirmed by MTB/RIF GeneXpert or detection sputum culture positive; 5. The identification of bacteria type is Mycobacterium tuberculosis; 6. Radiological examination of the lungs with lesions; 7. Non-infected the human immunodeficiency virus; 8. Sputum culture-confirmed susceptibility to rifampin, isoniazide and fluoroquinolones; 9. Women of childbearing age, that the urine analysis of whom are negative and agree to use the efficient contraception during the study period.
Exclusion criteria
Exclusion criteria: 1. Combined with extra pulmonary tuberculosis; 2. Allergic to any drug of treatment regimens; 3. Combined liver, kidney, metabolism, autoimmune diseases, endocrine, blood, nervous system diseases, mental disease, malignant tumor, long-term use of immunosuppressive agents; 4. HIV/AIDS patients; 5. Complication with Diabetic; 6. Being or breast-feeding; 7. Has Non-tuberculous mycobacterial disease; 8. Diagnosis was isoniazid resistance or rifampin resistance; 9. Patients who are not suitable for the study or who may not be able to complete the whole course of treatment, according to the researchers' judgment; 10. Attending any other clinical research simultaneously; 11. Those who gave up and withdrew halfway after joining the group participated in other clinical trials but had poor compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the rate of conversion at the end of the course of treatment;Cure rate;Recurrence rate;The rate of adverse event; | — |
Countries
China
Contacts
Public ContactKaijin XU
Zhejiang University
Outcome results
None listed