Acute focal cerebral ischemia
Conditions
Interventions
AIS vs control:N/A
Sponsors
Sun Yat-sen Memorial Hospital affiliated to Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
50 Years to 85 Years
Inclusion criteria
Inclusion criteria: AIS group: 1. The diagnosis of all AIS patients must meet the diagnostic criteria recognized by the 4th National Conference on Cerebral Vascular Diseases and patients must be confirmed new cerebral infarction; 2. All patients must be Acute onset with neurologic deficit symptoms and theirs signs lasting more than 24 hours. The diagnosis of all AIS patients must meet the diagnostic criteria recognized by the 4th National Conference on Cerebral Vascular Diseases and patients must be confirmed new cerebral infarction; 3. The period from onset to admission must be within 72 hours; 4. All patients and their families must sign informed consent. Control group: 1. Aged 60-80 years old; 2. Without history of cerebral infarction, cerebral hemorrhage, TIA and myocardial infarction 3.Conscious with autonomous ability to act.
Exclusion criteria
Exclusion criteria: 1. Asymptomatic cerebral infarction; 2. TIA; 3. Those who got sequelaes in previous stroke; 4. Patients with other diseases including malignant tumors, cerebral hemorrhage, history of surgery or trauma in the past 2 months, severe cardiopulmonary hepatorenal disease, systemic infection at the beginning of the study, autoimmune disease with or without Immunosuppressive therapy; 5. The time from onset to treatment exceeds 72 hours; 6. Patients with seizures; 7. Patients with disturbance of consciousness, serious sensory disturbances (blindness and deafness), severe aphasia, etc; 8. Patients suffered from cognitive impairment and other neuropsychiatric disorders before the onset of AIS; 9. Final diagnosis of non-cerebral infarction by magnetic resonance or clinical symptoms; 10. Patients who failed to complete cranial magnetic resonance after 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Differential expression of metabolic substances in AIS group and control group; | — |
Secondary
| Measure | Time frame |
|---|---|
| Relationship between patient's prognosis and metabolites; | — |
Countries
China
Contacts
Public ContactPan Suyue
Nanfang Hospital of Southern Medical University
Outcome results
None listed