Sudden hearing loss
Conditions
Interventions
Experimental group:intratympanic injection glucocorticoid
Control group:systemic glucocorticoid
Sponsors
Peking Unversity Shenzhen hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-65 years old; 2. A sudden onset of sensorineural hearing loss within 72 hours, at least in the three consecutive frequency of hearing loss of >=30dBHL; 3. Unilateral onset; 4. Confirmed diabetes; 5. The time of onset is within 30 days. 6.The hearing loss must have been deemed idiopathic following a suitable otolaryngologic evaluation, including medical and otologic history and extensive systems review, head and neck and otologic and neurotologic physical examination, audiometry, and imaging to rule-out structural or retrocochlear pathology, such as vestibular schwannoma, stroke, or demyelinating disease.
Exclusion criteria
Exclusion criteria: 1. External ear inflammation, tympanitis, or external auditory canal swelling in the ears; 2. The affected ear diagnosed with Meniere's disease, chronic suppurative otitis media or cholesteatoma of the middle ear, ear sclerosis; 3. History of congenital hearing loss; 4. History of ear barometric injury or trauma; 5. History of drug-induced deafness or syphilitic deafness; 6. Diabetes mellitus combined with diabetic foot, diabetic nephropathy, diabetic retinopathy, cerebral hemorrhage, and cerebrovascular embolism history; 7. Combined with active phase of tuberculosis, rheumatic disease, severe coronary atherosclerosis, severe psychosis, and pancreatitis; 8. Patients with chronic renal insufficiency, severe osteoporosis, alcoholism, head and neck malignant tumor and history of radiotherapy and chemotherapy; 9. Combined immunodeficiency virus, hepatitis B virus, hepatitis C virus, herpes zoster virus infection; 10. Chemotherapy drugs or immunosuppressants were used within the first two weeks; 11. The drug allergies involved in the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pure tone average, PTA; | — |
Countries
China
Contacts
Public ContactWeiqiang Yang
Peking Unversity Shenzhen hospital
Outcome results
None listed