HBV related acute-on-chronic liver failure
Conditions
Interventions
ETV 1mg/d:ETV 1mg/d
ETV 0.5mg/d:ETV 0.5mg/d
Sponsors
Third Affiliated Hospital, Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Aged 18 to 65 years old male and female; (2) History of positive serum HBsAg for over 6 months; (3) HBV DNA= 6log10 IU/ml; (4) eGFR=90 ml/min/1.73m^2; (5) Meet the ciriteria for ACLF of APASL consensus; (6) be able to provide a signed informed consent.
Exclusion criteria
Exclusion criteria: (1) Patient who is ongoing NAs when hepatitis flare (that result in this ACLF) occurs; (2) Women who are pregnant, nursing, or plan to bear babies in the next two years; (3) Patient who have malignants during enrollment, such as liver cancer, lung cancer, etc.; (4) Patient who complicated with other severe diseases, such as severe heart or pulmonary diseases, hematopathy, autoimmune diseases; (5) Patient who are allergic to NAs, especially entecavir; (6) Patient who have drugs or alcohol abuse; (7) Patient who have severe hepatoencephalopathy (grade IV) or other conditions which unable patients deglutition of pills; (8) Patient who need long-term use immune-modulating medicine, such as glucocorticoid, biologics; (9) Patient who co-infected with HAV, HCV, HEV, or HIV, etc.; (10) Patient who complicated with other liver diseases, such as autoimmune liver diseases, Wilson diseases, alcoholic liver diseases, or non-alcoholic liver diseases; (11) Patients with other conditions making whom inappropriate to the trail.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| survival at the third month; | — |
Secondary
| Measure | Time frame |
|---|---|
| survival at the 6th month;HBV DNA; | — |
Countries
China
Contacts
Public ContactYuankai WU
The Department of infectious diseases, Third Affiliated Hospital, Sun Yat-sen University
Outcome results
None listed