infertile woman with resistant thin endometrium
Conditions
Interventions
control:no drug use
study group1:granulocyte colony-stimulating factor
study group2:Macrophage granulocyte colony stimulating factor
Sponsors
Women's Hospital, School of Medicine, Zhejiang University
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. women aged 20–40 years; 2. previously cancelled at least one cycle because of thin unresponsive endometrium(<7mm)during IVF programs; 3. previous treatment of unresponsive endometrium with oral/vaginal estradiol, sildenafil citrate; 4. lack of contraindications for CSF treatment(sickle cell disease, chronic neutropenia, known past or present malignancy, renal insufficiency, upper respiratory infection, pneumonia, and congenital fructose intolerance); 5. personal agreement for such still experimental therapy; 6. no PGD or PGS; 7. undergoing IVF in a frozen cycle with own embryos.
Exclusion criteria
Exclusion criteria: 1. Presence of systemic diseases, endocrine disorders, sickle cell disease, chronic neutropenia, and history of malignancy and renal insufficiency; 2. Presence of Ashermans syndrome, fibroids, and polyps on hysteroscopy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| clinical pregnancy rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| endometrial thickness;endometrial morphology;endometrial blood flow;chemical pregnancy rate;ectopic pregnancy rate;singleton pregnancy rate;multiple pregnancy rate;abortion rate;implantation rate; | — |
Countries
China
Contacts
Public ContactZhang Dan
Women's Hospital, School of Medicine, Zhejiang University
Outcome results
None listed