severe fever with thrombocytopenia syndrome
Conditions
Interventions
Placebo group: Symptomatic treatment + glucose injection
Sponsors
Beijing Institute of Microbiology and Epidemiology
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Based on the criteria of severe fever with thrombocytopenia syndrome as defined by the Chinese Ministry of Health.
Exclusion criteria
Exclusion criteria: Patients younger than 18 years of age; pregnancy, nursing mothers; Patients with acute infection of HBV, HCV, HIV, syphilis or pathogens can cause similar symptoms with SFTSV (such as rickettsiae, borrelia burgdor feri and babesia); Patients had a history of gout or in the treatment of gout or hyperuricemia; patients had hereditary xanthuria, or had a history of low uric acid ( 450 ms, while using QT/QTc interval prolonging drugs or drugs that can lead to electrolyte imbalance, such as diuretics. The following index of laboratory biochemical examination was higher than the level 2 of the common adverse event evaluation criteria (CECAE v4.03): creatinine: > 3 UNL, AST, ALAT, alkaline phosphatase, >5.0 UNL, total bilirubin: >3.0 UNL; Pateints who are unsuitable for the trial for other reasons according to the researcher's evaluation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| case fatality rate of severe fever with thrombocytopenia syndrome;Viral load clearance rate of severe fever with thrombocytopenia syndrome virus; | — |
Secondary
| Measure | Time frame |
|---|---|
| time for the main clinical symptom disappeared;days for platelet and white blood cells recovered to the normal level;time for the main clinical symptom disappeared; | — |
Countries
China
Contacts
Public ContactLiu Wei
Beijing Institute of Microbiology and Epidemiology
Outcome results
None listed