functional constipation
Conditions
Interventions
Low dosage of Xylooligosaccharide:Low dosage of Xylooligosaccharide
Medium dosage of Xylooligosaccharide:Medium dosage of Xylooligosaccharide
High dosage of Xylooligosaccharide:High dosage of Xylooligosaccharide
low dosage of Fructooligosaccharide:low dosage of Fructooligosaccharide
High dosage of Fructooligosaccharide:High dosage of Fructooligosaccharide
Sponsors
Affiliated Hospital of Jiangnan University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-65 years old; 2. Rome ? standards of the functional constipation developed and officially released by American Gastroenterological Association (AGA) in 2016 will be used: (1) meeting the following two or more standards: 1) defecation difficulties (at least once every 4 defecations); 2) whose stools are block-shaped or hard (at least once every 4 defecations); 3) has defecating unfinished feeling (at least once every 4 defecations); 4) has anorectal obstruction or obstruction feeling (at least once every 4 defecations); 5) needs artificial assistance (at least once every 4 defecations); 6) <3 defecations per week; (2) Almost no loose stools without the usage of laxatives; (3) diagnosis of irritable bowel syndrome without adequate proofs.*Before diagnosis, symptoms appeared at least 6 months ago, and the above diagnostic criteria were met for 3 months.
Exclusion criteria
Exclusion criteria: 1. Abdominal and/or intestinal surgery, appendectomy, cholecystectomy; 2. Rectal prolapse and/or grade 3-4 internal hemorrhoids diagnosed according to AGA diagnostic criteria; 3. Using drugs that affect the intestinal motility, such as: calcium antagonists, nitrates, anti-muscarinic drugs; 4. Take high-dose stimulant laxatives in the past 5 years (three times a week) 5. Is diagnosed IBS or Functional Abdominal Pain Syndrome according to Rome IV; 6. Is identified as grade 5 and above abdominal pain according to the visual analogue scale; 7. Suffering from intestinal obstruction.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| constipation scoring system, CSS/cleveland clinic score, CCS;patient assessment of constipation quality of life questionnaire, PAC-QOL;Bristol stool form scale, BSFS;The Healthy Lifestyle and Personal Control Questionnaire, HLPCQ;16S sequencing of gut microbiota; | — |
Countries
China
Contacts
Public ContactZhang Feng
Affiliated Hospital of Jiangnan University
Outcome results
None listed