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Exploring the roles and underlying molecular mechanisms of APE1 deficiency mediating diabetic cardiomyocyte injury

Exploring the roles and underlying molecular mechanisms of APE1 deficiency mediating diabetic cardiomyocyte injury

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR1800015886
Enrollment
Unknown
Registered
2018-04-26
Start date
2018-06-01
Completion date
Unknown
Last updated
2018-04-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

diabetic cardiomyocyte injury

Interventions

diabetic cardiomyopathy:nothing

Sponsors

Affiliated Hospital of Guangdong Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
38 Years to 68 Years

Inclusion criteria

Inclusion criteria: Diabetic cardiomyopathy patients were included in the following criteria: 1. diagnosis of diabetes mellitus (especially type 2 diabetes) for more than 5 years; 2. the clinical manifestation of heart failure; 3. Enlargement of the heart with impaired cardiac contractility and diastolic dysfunction in the absence of cardiac enlargement; 3. exclude heart failure caused by other heart diseases such as hypertensive heart disease, coronary heart disease and rheumatic heart valve disease. Exclude other complications of diabetes, such as retina and kidney disease, and support diagnosis.

Exclusion criteria

Exclusion criteria: Diagnosed diabetes (especially type 2 diabetes mellitus) below 5 years of history. The hypertensive heart disease, coronary heart disease and rheumatic heart disease and other heart disease caused by heart failure. The other diabetic complications, such as retinal and renal lesions diagnosis support.

Design outcomes

Primary

MeasureTime frame
EF;

Countries

China

Contacts

Public ContactRunmin Guo

Guangdong Medical University

1314ivu@126.com+86 13709639792

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026