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Clinical study on the maintenance treatment with chidamide for T- cell acute lymphoblastic leukemia after allogeneic hematopoietic stem cell transplantation

Effect on mintenance treatment with chidamide for T- cell acute lymphoblastic leukemia after allogeneic hematopoietic stem cell transplantation: A I/II phase, prospective, single center, open lable study.

Status
Recruiting
Phases
Phase 2
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR1800015885
Enrollment
Unknown
Registered
2018-04-26
Start date
2018-05-01
Completion date
Unknown
Last updated
2018-04-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

T-cell acute lymphoblastic leukemia

Interventions

Sponsors

Department of hematology, Xinqiao hospital, Army Medical University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. The patients with T-cell acute lymphoblastic leukemia undergone allogeneic hematopoietic stem cell transplantation after inducion therapy and 2-cycle intensive treatment with high dose methotrexate; 2. The hematopoietic reconstitution is stable at day 30 to 45 after allogeneic hematopoietic stem cell transplantation and the acute lymphoblastic leukemia is complete remission; 3. The patients age 14 to 55 year old, and the KPS is over 60. The estimated survival is over three months; 4. The important organs are function,such as heart and brain.

Exclusion criteria

Exclusion criteria: 1. serious systemic organ dysfunction; 2. Patient with malignant tumor that needs to be treat; 3. The patients with clinical symptom of brain dysfunction or serious psychiosis that can't understand or obey the study; 4. Patients that can't followed up as scheduled.

Design outcomes

Primary

MeasureTime frame
1-year disease-free survival;

Secondary

MeasureTime frame
1-year oversurvival;1-year relapse rate;

Countries

China

Contacts

Public ContactZhang Cheng

Department of hematology, Xinqiao hospital, Army Medical University

chzhang2014@163.com+86 023-687774209

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026