Major depressive disorder
Conditions
Interventions
Ketamine group:single ketamine 0.5 mg/kg IV infusion
S-ketamine group:single S-ketamine 0.5 mg/kg IV infusion
R-ketamine group:single R-ketamine 0.5 mg/kg IV infusion
Sponsors
The Affiliated Wuxi Mental Health Center of Nanjing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Responding to the diagnosis of Major Depressive Disorder according to DSM IV; 2. Introducing a single depressive episode or recurrent unipolar; 3. Informed consent signed.
Exclusion criteria
Exclusion criteria: (1) Lifetime history of psychotic features, diagnosis of schizophrenia or any other psychotic disorder, or diagnosis of bipolar disorder; (2) Patients judged clinically to be at serious and imminent suicidal or homicidal risk; (3) Women who are either pregnant or nursing; (4) Serious, unstable medical illnesses including hepatic, renal impairment, respiratory (including obstructive sleep apnea, or history of difficulty with airway management during previous anesthetics), cardiovascular (including ischemic heart disease and uncontrolled hypertension), endocrinologic, neurologic (including history of severe head injury), immunologic, or hematologic disease; (5) Clinically significant abnormal findings of laboratory parameters, physical examination, or ECG; (6) Patients who have a positive urine toxicology for illicit substances at screening and within 24 hours of the infusion; (7) Patients with one or more seizures without a clear and resolved etiology; (8) Previous recreational use of ketamine; (9) Hypertension (systolic BP >160 mm Hg or diastolic BP >90 mm Hg) not controlled by diuretic or beta-blocker therapy alone or in combination.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Depression Rating Scale; | — |
Countries
China
Contacts
Public ContactGuoqiang Wang
The Affiliated Wuxi Mental Health Center of Nanjing Medical University
Outcome results
None listed