Childhood acute megakaryoblastic leukemia
Conditions
Interventions
Case series:Mitoxantrone + cytarabine + granulocyte colony-stimulating factor
Sponsors
Children's Hospital of Soochow University
Eligibility
Sex/Gender
All
Age
No minimum to 18 Years
Inclusion criteria
Inclusion criteria: 1. All AMKL including DS-AMKL and Non DS-AMKL exception with -5,-7,5q-,7q-; 2. Younger than 18 years old; 3. TMD should be excluded; 4. Newly diagnosed patients without treatment, excluding single dose of intrathecal injection and use of hydroxyurine or cytarabine (cytarabine was used no more than 5 days, with a total dose less than 1g)for hyperleukin (WBC > 50 * 10^9/L at diagnosis); anticancer therapy for this malignancy within 2 weeks before study entry with the exception of IT therapy, hydroxyurea, or low-dose cytarabine as stated above; 5. Patients or / and guardians who have signed the Informed Consent Form; 6. Patients predicted life would be more than 3 months.
Exclusion criteria
Exclusion criteria: 1. Use of concomitant chemotherapy, radiation therapy, or immunotherapy other than receiving systemic treatment followed this protocol; 2. Use of anticancer therapy for this malignancy within 2 weeks before study entry with the exception of IT therapy, hydroxyurea, or low-dose cytarabine as stated above; 3. Any significant concurrent disease, illness, or psychiatric disorder that would compromise patient safety or compliance, interfere with consent, study participation, follow up, or interpretation of study results.Under such circumstances, all the research institutes are required to report directly to the person in charge of the project and decide whether to the exclude the case; 4. ECOG score 4.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| remission state of bone marrow;remission state of hematology;disappear of extramedullary invasion;event-free survival;overall survival;early mortality rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| cumulative disease rate of relapse; | — |
Countries
China
Contacts
Public ContactHu Shaoyan
Children's Hospital of Soochow University
Outcome results
None listed