Refractory/relapse AML of children
Conditions
Interventions
Reinduction I:Dec+IDAG
Reinduction II:Dec+HAG
Sponsors
Children's Hospital of Soochow University
Eligibility
Sex/Gender
All
Age
No minimum to 18 Years
Inclusion criteria
Inclusion criteria: 1. All patients meet with the criteria of refractory/ relapse of AML; 2. Newly diagnosed of AML with -5, -7, 5q-, 7q-; 3. Patients or / and guardians who have signed the Informed Consent Form; 4. Patients predicted life would be more than 3 months.
Exclusion criteria
Exclusion criteria: 1. Use of concomitant chemotherapy, radiation therapy, or immunotherapy other than receiving systemic treatment followed this protocol; 2. Patients with WBC more than 50×10^9/L after treated with decitabine and cytarabin for 5 days; 3. Any significant concurrent disease, illness, or psychiatric disorder that would compromise patient safety or compliance, interfere with consent, study participation, follow up, or interpretation of study results.Under such circumstances, all the research institutes are required to report directly to the person in charge of the project and decide whether to the exclude the case; 4. ECOG score 4.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| remission state of bone marrow;remission state of hematology;disappear of extramedullary invasion;event-free survival;overall survival;cumulative disease rate of relapse; | — |
Secondary
| Measure | Time frame |
|---|---|
| early mortality rate; | — |
Countries
China
Contacts
Public ContactHu Shaoyan
Children's Hospital of Soochow University
Outcome results
None listed