Advanced Non Small Cell Lung Cancer
Conditions
Interventions
Pumping group:endostar continuous intravenous infusion by pumping
Normal infusion group:endostar normal infusion group
Sponsors
Fujian Cancer Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) 18-75 years of age; (2) Cytologically or histologically proven diagnosis of NSCLC; (3) Stage IV according to AJCC (7th edition of 2010); (4) ECOG performance status 0-2; (5) No prior chemotherapy and immunotherapy (postoperative adjuvant therapy must be completed=6 months); (6) Radiotherapy must be completed=4 weeks and the acute toxicities must been restored; previous radiotherapy lesion cannot be target tumor lesion unless progress; (7) EGFR and ALK mutations treated with mono corresponding targeted drugs and progressive; (8) At least one target tumor lesion can be measured by CT or MRI(the long diameter of tumor lesion=10mm, the short diameter of lymph node lesions=15mm and the target lesions not be treated with radiotherapy or freezing and so on); (9) Life expectancy of at least 3 months; (10) Adequate hematologic, hepatic and renal function to accept chemotherapy; electrocardiogram was normal; (11) Follow research requirements and follow-up procedures, signed informed consent form; (12) clinical data integrity.
Exclusion criteria
Exclusion criteria: (1) Serious violation of the inclusion criteria; (2) Can not follow the research requirements and follow-up procedures; (3) the change or death occurring during follow-up and no related to the experimental factors.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| objective response rate;progression free survival; | — |
Countries
China
Contacts
Public ContactJiang Kan
Fujian Cancer Hospital
Outcome results
None listed