Gestational diabetes mellitus
Conditions
Interventions
Control group:Placebo
XOS group:Xylooligosaccharide
Sponsors
Affiliated Hospital of Jiangnan University (formerly Wuxi Third People's Hospital)
Eligibility
Sex/Gender
Female
Age
22 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. Meeting standards for the high-risk of GDM ; 2. Aged 22-40 years; 3. Monocyesis; 4. Have detailed medical history and routine pregnancy test in our hospital; 5. Han nationality, living locally for at least 1 year and has fixed residence.
Exclusion criteria
Exclusion criteria: 1. Diagnosed with type 1 or type 2 diabetes at early pregnancy examination; 2. Suffering from heart disease, urinary tract infections, renal insufficiency or uremia, thyroid or pituitary dysfunction, anemia, cholecystitis, gallstones, inflammatory bowel disease, Cushing syndrome, mental disorders, autoimmune diseases, gastrointestinal ulcers, severe infectious diseases, tumors and other diseases; 3. Have used antibiotics in the past 1 month and lasted for 3 days or more; 4. Have undergone bowel surgery or used any medicine or surgery to lose weight; 5. Long-term using of hormone drugs; 6. Pregnant women who have a history of preterm birth, a history of childbirth of fetal macrosomia, and a history of miscarriage and stillbirth.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fasting blood glucose;Homeostasis model assessment-insulin resistance, HOMA-IR; | — |
Secondary
| Measure | Time frame |
|---|---|
| HbA1c;Postprandial blood glucose;Triglyceride;Total cholesterol;Body Mass Index;IL-2;IL-4;IL-6;IL-10;IL-17A;TNF-a;IFN-?;Glutathione;Catalase;Superoxide dismutase;Malondialdehyde;Nitric Oxide;Fasting insulin;Postprandial insulin;Estradiol;Progesterone;Cortisol;Adiponectin;Leptin;Gut microbiota;Prevalence of GDM; | — |
Countries
China
Contacts
Public ContactFeng Zhang
Affiliated Hospital of Jiangnan University (formerly Wuxi Third People's Hospital)
Outcome results
None listed