Epilepsy
Conditions
Interventions
Case series:deep brain stimulation
Sponsors
Xuanwu Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Be between 18 and 60 years of age at the time of surgery; 2. Failure of pharmacological therapies (pharmacoresistant epilepsy) (persistent seizures despite at least two anti-epileptic treatments used at the optimal dose for at least 2 years); 3. Bilateral or multifocal epilepsy; 4. Patients with refractory epilepsy who have difficulty in resection or who refuse to undergo resection surgery; 5. persistent partial-onset seizures after resection surgery; 6. Patient or legal guardian understands study procedures and has voluntarily signed an informed consent; 7. Patient who is willing to abide by relevant regulations and complete study evaluations before the deadline.
Exclusion criteria
Exclusion criteria: 1. Patient with brain tumors or other degenerative disorders of the central nervous system; 2. Patient with mental disorders and the relevant examination cannot be acquired; 3. Patient with structural changes in the thalamus; 4. Patient with severe cognitive impairment, Intelligence quotient less than 55; 5. Patient with generalized or special types of hereditary epilepsy; 6. Woman of childbearing potential without effective contraception or pregnant or lactating or patient who have a high risk of bleeding; 7. Patient with other serious physical diseases or severe abnormalities of liver and kidney function, which affect the follow-up; 8. There are objective factors that cannot complete the follow-up (economic factors, traffic factors, etc.); 9. Abnormal laboratory tests during the screening period, or other laboratory abnormalities that are clinically significant; 10. Patient who is unwilling to sign the informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in Seizure Rate;quality of life in epilepsy;Seizure Severity; | — |
Secondary
| Measure | Time frame |
|---|---|
| stimulation parameters;Electrodes resistance; | — |
Countries
China
Contacts
Public ContactTao Yu
Xuanwu Hospital, Capital Medical University
Outcome results
None listed