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Study on the pathogenesis of acute cerebral infarction and the mechanism of Chinese medicine intervening neural network effect

Study on the pathogenesis of acute cerebral infarction and the mechanism of Chinese medicine intervening neural network effect

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1800015810
Enrollment
Unknown
Registered
2018-04-22
Start date
2018-05-01
Completion date
Unknown
Last updated
2018-04-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cerebral infarction

Interventions

test grop:Standard oral medicine + Intravenous infusion of Ozagrel Sodium for Injection+intravenous infusion of Xingnaojing injection + oral Huatan Tongluo Decoction
control grop:Standard oral medicine + Intravenous infusion of Ozagrel Sodium for Injection+intravenous infusion of Xingnaojing injection +Analogue agent for oral Huatan Tongluo Decoction
Healthy subjects group:no

Sponsors

Dongzhimen Hospital, Beijing University of Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
35 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Conforming to the diagnostic criteria of cerebral infarction; 2. The location of cerebral infarction is unilateral basal ganglia or corona radiata; 3. No distrubance of consciousness; 4. Cerebral infarction for the first time and no history of organic encephalopathy; 5. The incidence of cerebral infarction is within 48 hours; 6. Conforming to the diagnosis of wind phlegm obstructing collaterals in TCM with stroke; 7. Aged 35 and 75 years; 8. The NIHSS score is 5-22 points; 9. Participants in the test need to have informed consent; 10. Healthy subjects: right handedness, no history of mental illness and history of neuropathy. The age of healthy subjects is matched with patients.

Exclusion criteria

Exclusion criteria: 1. Patients with severe infection or upper gastrointestinal bleeding on admission; 2. Patients who have been treated with thrombolytic therapy; 3. Patients with cerebral infarction due to brain tumor, traumatic brain injury and hematopathy; 4. Patients with cerebral embolism due to rheumatic heart disease, coronary heart disease and other heart diseases with atrial fibrillation; 5. Patients suffering from severe diseases such as liver, kidney, hematopoietic system, endocrine system and osteoarthropathy; 6. Patients with mental disorders or serious dementia; 7. Patients with idiopathic epilepsy or secondary epilepsy; 8. Patients who took sedatives and hypnotics 3 days ago before the examination.

Design outcomes

Primary

MeasureTime frame
electroencephalogram;Brain functional magnetic resonance imaging;NIHSS;the Barthel index of ADL;mRS;—

Countries

China

Contacts

Public ContactLi Zhou

Dongzhimen Hospital, Beijing University of Chinese Medicine

zhouljk7211@163.com+86 13261578636

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026