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Comparison of Intravenous and Topical Tranexamic Acid in Total Knee Arthroplasty

Comparison of Intravenous and Topical Tranexamic Acid in Total Knee Arthroplasty

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1800015793
Enrollment
Unknown
Registered
2018-04-20
Start date
2018-04-20
Completion date
Unknown
Last updated
2018-04-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

knee arthritis

Interventions

The Intravenous Group:administered TXA 10 mg/kg IV (Reyong, Shandong, China) 10 minutes prior to tourniquet deflation
the Topical Group:1.0 g TXA diluted in 50 ml of normal saline was injected into the surgical site

Sponsors

Shaanxi Province People Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1) =18 years old; 2) American Society of Anesthesiologists (ASA) score =3; 3) planned TKA due to degenerative arthritis of the knee.

Exclusion criteria

Exclusion criteria: 1) cardiovascular problems (e.g., myocardial infarction, atrial fibrillation, angina); 2) cerebrovascular conditions (e.g., previous stroke or previous vascular surgery); 3) thromboembolic disorders; 4) renal insufficiency.

Design outcomes

Primary

MeasureTime frame
VAS scores;HB;—

Countries

China

Contacts

Public ContactWei Ling

Shaanxi Province People Hospital

dangshajie@163.com+86 18991290829

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026