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The epigenetic mechanism of low birth weight/ small for gestational age of offspring exposure to high maternal estradiol level in first trimester pregnancy

High maternal serum estradiol in first trimester contributes to small-for-gestational-age through DNMT1-mediated up-regulation of CDKN1C

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR1800015772
Enrollment
Unknown
Registered
2018-04-20
Start date
2013-06-27
Completion date
Unknown
Last updated
2018-04-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

maternal high estradiol intrauterine environment

Interventions

Case series:NO

Sponsors

Women's Hospital, School of Medicine, Zhejiang University, China
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 40 Years

Inclusion criteria

Inclusion criteria: maternal serum samples were collected at 8 weeks of gestation , aspirated fetal tissues were collected from MFPR, and fetal tissues of singleton pregnancies were collected from elective terminations of unintended normal pregnancies, as a control group. Surgeries were performed at 8 weeks gestation, Umbilical cord blood (UCB) and placenta tissues from twins were collected.

Exclusion criteria

Exclusion criteria: The patients with obstetric complications, such as gestational diabetes mellitus, hypertension in pregnancy, and intrahepatic cholestasis of pregnancy, were excluded from this study. The parents with alcohol consumption in pregnancy and smoking were also excluded.

Design outcomes

Primary

MeasureTime frame
estradiol;expression and methylation of impringting in abandoned fetal tissues;—

Countries

China

Contacts

Public ContactHuang He-Feng

Women' Hospital, School of Medicine, Zhejiang University

hhf57@zju.edu.cn+86 18017310186

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026