primary and recurrent high grade gliomas
Conditions
Interventions
Case series:apatinib + Temozolomide + radiotherapy
Sponsors
Gansu Province Cancer Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. 18 years of age or older; 2. a newly diagnosed grade WHOIII/IV glioma after surgery, or recurrent grade WHOIII/IV glioma after surgery and / or radiotherapy and chemotherapy, was confirmed by histopathology; 3. ECOG score: 0-2 points; 4. The main organ function:HGB=90 g/L; ANC=1.5*10^9/L; PLT=80*10^9/L; Biochemical examination: ALB=30g / L, ALT and AST <2ULN, TBIL =1.5ULN; serum Cr=1.5ULN; 5. coagulation function: INR=1.5ULN, APTT=1.5ULNULN; 6. The subjects voluntarily joined the study, informed consent, good compliance, with the follow-up.
Exclusion criteria
Exclusion criteria: 1. pregnant or lactating; 2. After suffering from high blood pressure and antihypertensive medications can not fall within the normal range (systolic blood pressure> 150 mmHg, diastolic blood pressure> 100 mmHg); above the level of suffering I coronary heart disease or arrhythmia (including QT interval of =440 ms) and Class I cardiac insufficiency (according to NCI-CTC AE 3.0); Patients who take antiarrhythmic drugs or have underlying heart disease, bradycardia, and electrolyte disorders;The occurrence of arterial thrombosis, cerebrovascular accident; 3. obvious factors of oral drug absorption, such as inability to swallow, nausea, emesis, chronic diarrhea and intestinal obstruction; Patients with clear gastrointestinal bleeding concerns, including the following situations: local active ulcerative lesions, and defecate occult blood (++); the history of hemorrhage in the digestive tract within 6 months; 4. Patients treated with thrombolytic therapy, anticoagulant or vitamin K antagonist such as warfarin, heparin or its analogues; In the standardization of the prothrombin time ratio (INR) under the premise of 1.5 or less, allowing to use low-dose warfarin (1 mg orally, once per day), small dose of heparin (adult daily dose is 06000 ~ 12000 U) or low-dose aspirin (80 mg daily dose in to 100 mg); 5. Severe liver and renal insufficiency (cet-4);3/4 levels of transaminase and total bilirubin increased; 6. Within 30 days after the operation or the wound has not healed; 7. history of mental illness or psychotropic substance abuse; 8. Surgical history of other diseases in the skull; 9. patients who physicians suggest not be included; 10. All patients should have a head MRI scan a week before the program begins, such as intracranial hemorrhage.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| SPFS;PFS;OS; | — |
Secondary
| Measure | Time frame |
|---|---|
| ORR;QoL;Changes in hormone dosage and the dosage of intracranial edema dehydrated drugs; | — |
Countries
China
Contacts
Public ContactGao Liying
Gansu Province Cancer Hospital
Outcome results
None listed