postoperative delirium and postoperative cognitive dysfunction
Conditions
Interventions
cleansing enema group:Cleaning enema with 39-41 degree normal saline before operation
Control group:No cleaning enema before operation
Sponsors
Guangzhou Women and Children's Medical Center
Eligibility
Sex/Gender
All
Age
65 Years to 85 Years
Inclusion criteria
Inclusion criteria: Elderly patients (> 65 years old) undergoing hip or knee replacement orthopedics and major femoral surgery.
Exclusion criteria
Exclusion criteria: 1. with a score on the mini-mental state examination (MMSE) at screening of 23 or less; 2. with disease of the central nervous system; 3. were taking tranquillisers or antidepressants; 4. had been admitted for neurological or cardiac surgery; 5. previously undergone neuropsychological testing; 6. unwilling to comply with the protocol or procedures or were unable to understand the language used; 7. had any severe visual or auditory disorders; were illiterate; 8. illiteracy; 9. with Parkinsons disease; 10. alcoholism, or drug dependence; 11. if they were not expected to be alive for discharge from hospital or to be able to complete tests at 3 months after surgery; 12. Bone cement was used in the operation; 13. had intestinal disorders such as Crohn's disease, enteritis and diarrhea.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence rate of postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence rate of postoperative cognitive dysfunction;Pain score;vital signs;Adverse events; | — |
Countries
China
Contacts
Public ContactXingrong Song
Guangzhou Women and Children's Medical Center
Outcome results
None listed