Lung Cancer
Conditions
Interventions
Gold Standard:Fleischner Society 2017 Guidelines for Management of Incidentally Detected Pulmonary Nodules in Adults
ctNDA 
Lung 
cancer 
autoantibody 
Sponsors
Guangdong General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Pulmonary occasional nodules subject detected by LDCT; 2. Age >=18 year, and sign ICF; 3. Never received any surgery,radiotherapy,chemotherapy or moleculary targeted anti-tumor treatment; 4. Never diagnosed NSCLC by tumor histology or cytology; 5. No specific tuberculosis, inflammation or pulmonary benign nodules which diagnosed clearly; 6. At least one measurable pulmonary benign nodules by LDCT examination; 7. Exclude having obvious maligancy pulmonary tumor indications people which define as CEA increased above 10 times normal value; 8. Exclude having obvious benign pulmonary nodules indications people which define as tuberculosis or inflammation indicator positive; 9. Subject was consent and able to follow the study visit plan, and to provide 10ml blood sample prior to any clinical treatment and future follow-up visit, and to cooperate other study procedures.
Exclusion criteria
Exclusion criteria: 1. Subject have serious disease that may likely impact follow-up and short-term survial judged by investigaor; 2. Subject had been received any surgery,radiotherapy,chemotherapy or moleculary targeted anti-tumor treatment; 3. Subject had been received antituberculous or antifungal treamtent wich target on nodules; 4. Subject have specific active effection, including but not limited pneumonia; 5. Subject have obvious maligancy pulmonary tumor indications people which define as CEA increased above 10 times normal value; 6. Subject have obvious benign pulmonary nodules indications people which define as tuberculosis or inflammation indicator positive; 7. Subject is not appropriate for enrollment that judge by investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| blood ctDNA methylatiion;Lung cancer autoantibody detection; | — |
Countries
China
Contacts
Public ContactGuibin Qiao
Guangdong General Hospital
Outcome results
None listed