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Modified Box Ablation in Patients with Persistent Atrial Fibrillation Who underwent Circumferential Pulmonary Vein Isolation and Individualized Substrate Modification

A Randomized Study of Modified Box Ablation in Patients with Persistent Atrial Fibrillation Who underwent Circumferential Pulmonary Vein Isolation and Individualized Substrate Modification

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1800015747
Enrollment
Unknown
Registered
2018-04-18
Start date
2018-04-30
Completion date
Unknown
Last updated
2018-04-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

atrial fibrillation

Interventions

A:Modified BOX ablation + CPVI plus left atrial substrate modification
B:CPVI plus left atrial substrate modification

Sponsors

Shanghai General Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
30 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Aged 30 to 80 years old; 2. AF lasting 7 days to 5 years; 3. Agree and sign informed consent; 4. Patients must be willing and able to comply with all peri-ablation and follow-up requirements.

Exclusion criteria

Exclusion criteria: 1. Paroxysmal AF (AF lasting 55mm (2D echocardiography, long axis view beside sternum); 7. Contra-indication to heparin or oral anticoagulant therapy; 8. Creatinine clearance <30ml/min; 9. Pregnant women.

Design outcomes

Primary

MeasureTime frame
Freedom from documented AF/AT episodes > 30 seconds at 12 months after one ablation procedure without antiarrhythmic medications;—

Secondary

MeasureTime frame
Incidence of complications;Procedure time;Fluoroscopy time;Ablation time;Freedom from documented AF episodes > 30 seconds at 12 months after one ablation procedure without antiarrhythmic medications;Freedom from documented AT episodes > 30 seconds at 12 months after one ablation procedure without antiarrhythmic medications;Relationship of acute AF termination to long-term procedural outcome;Relationship of left atrail substrate type to long-term procedural outcome;Relationship of posterior wall isolation to long-term procedural outcome;—

Countries

China

Contacts

Public ContactShaowen Liu

Shanghai General Hospital

shaowen.liu@hotmail.com+86 13817825235

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026