Non-alcoholic fatty liver disease
Conditions
Interventions
Control:control starch
Sponsors
Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Non-alcoholic fatty liver disease dignosed by ultrasound test in recent one year; Aged 18-70 years old; Written informed consents must be obtained.
Exclusion criteria
Exclusion criteria: Subjects with diabetes mellitus;Subjects with an alcohol consumption history of more than 20 g per day for men and more than 10 g per day for women; Subjects with acute or chronic gastrointestinal diseases; Pregnant, breastfeeding women or women planning to get pregnant are excluded; Subjects suffering diseases or those who have consumed antibiotics within 3 weeks before participation in the trial; Subjects with hepatic virus infections, autoimmune liver disease, Wilsons disease, or other liver diseases will be ruled out;Subjects who have hyperthyroidism, hypothyroidism, uncontrolled hypertension, chronic kidney disease, cardiac infarction or heart failure in recent half year; Subjects prescribed with drugs or other Chinese or western medicines (except for regular contraceptives); Subjects who have used tetraiodothyronine or glucocorticoids which will influence glucose metabolism;Subjects expected to have poor compliance;Subjects who have used weight loss medication or program in the previous 3 months;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| intrahepatic triglyceride content; | — |
Secondary
| Measure | Time frame |
|---|---|
| stiffness;quantitative determination of liver fat;controlled attenuation parameter;subcutaneous fat area;visceral fat area;Anthropometry;glycemic control;lipid profiles;liver enzymes;biochemical indexes;cytokines;gastrointestinal hormones;compositional alterations of gut microbiota; | — |
Countries
China
Contacts
Public ContactWeiping Jia
Outcome results
None listed