Mobilization of healthy donors for allogeneic hematopoietic stem cell transplantation
Conditions
Interventions
Test group:long acting G-CSF d1
Control group:short acting G-CSF 10ug/kg d1-4
Sponsors
The Second Affiliated Hospital of Army Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1) relationship between allogeneic hematopoietic stem cell transplantation of healthy donors; 2) aged 18-55 years; 3) weight 50-100Kg; 4) normal heart function; 5) normal liver and kidney function; 6) hepatitis index examination negative; 7) detection of cytomegalovirus negative; 8) normal ECG; 9) ultrasound of abdomen, chest normal; 10) Voluntary participants, informed consent.
Exclusion criteria
Exclusion criteria: 1) Uncontrolled active infection; 2) unrelated allogeneic hematopoietic stem cell transplantation; 3) HIV antibody, syphilis antibody positive; 4) with allergic diseases or allergies, or of the goods or other genetically engineered Escherichia coli derived from biological products allergy; 5) serious spirit or nervous system disorders, effects of informed consent and/or adverse reaction statement or observation; 6) in lactation.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| T cell subgroup;B cell subgroup;GFU-GM;Reconstructive time of leukocyte;Reconstructive time of platele;the ratio of GVHD;headache;bone pain;fever;muscle pain;liver damage;renal damage;Splenomegaly;the ratio of relapse;Hospitalization expenses; | — |
Primary
| Measure | Time frame |
|---|---|
| leukocyte;hemoglobin;Platelet;Mononuclear cells;CD34+ cells; | — |
Countries
China
Contacts
Public ContactZhang Xi
The Second Affiliated Hospital of Army Medical University
Outcome results
None listed