sepsis-induced myocardial dysfunction
Conditions
Interventions
volunteers:no
septic patients with sepsis-induced myocardial dysfunction:no
septic patients without sepsis-induced myocardial dysfunction:no
Sponsors
Tongde Hospital of Zhejiang Province
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-85 years old men and women; 2. ICU in patients with sepsis (with Sepsis 3 APACHE, II = 8); 3. can do at least 28 days of research treatment; 4. has written informed consent signed by the Censorship Committee (IRB) / Independent Ethics Committee (IEC) and the privacy instructions specified by the state regulations.
Exclusion criteria
Exclusion criteria: 1. researchers judged the survival time of 25 score; 3. is known to have serious and clinically significant diseases (such as the New York Heart Association grading (NYHC) classification of IV grade congestive heart failure) or the inability to accept renal replacement therapy (such as hemofiltration, hemodialysis, or peritoneal dialysis); Severe renal dysfunction; 4. To be known to have chronic active hepatitis, alanine aminotransferase > 4 times the upper limit of normal value (ULN) and aspartate ammonia. Basal transferase > 4 * ULN, or total serum bilirubin >2 * ULN; 5. To be known to have a history of human immunodeficiency virus infection; 6. To be known to have abnormal amino acid metabolism, such as phenylketonuria, homocysteinuria or tyrosinemia; 7. had severe dyslipidemia, triglyceride level >2 * UN or >4.52mmol/L (>400mg/dL); 8. severe hyperglycemia, blood glucose >20mmol/L (>360mg/dL); 9. has clinically significant plasma electrolyte abnormalities, such as sodium ( 150mmol/L) and potassium (5.5mmol/L), calcium (3.0mmol/L) or phosphorus (1.62mmol/L); 10. To be known for pregnancy or lactation; On the first 30 days of L. recruitment, those who used antitumor chemotherapy drugs were treated with corticosteroids; 11. researchers believe that it is not suitable for any participant in the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 16S rDNA V3-V4 hypervariable regions of all bacteria in the stool samples;levels of D lactate;I-FABP, markers of inflammation and myocardial injury in the blood would be measured. T cell subsets would be sorted, and the expression of TLRs, NF-?B and PI3K / Akt in the blood;the activity of ureal ?-glucuronidase; | — |
Countries
China
Contacts
Public ContactJianbiao Meng
Tongde Hospital of Zhejiang Province
Outcome results
None listed