gastric cancer
Conditions
Interventions
experimental group:DC-CIK immunothreapy which pulsed with gastric tumor membrane proteins
Sponsors
Lanzhou University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Post-operation pathologically confirmed distal gastric cancer patients; 2. Aged 18-70 years old; 3. ECOG physical status score 0-2 or KPS = 70 points; 4. The results of laboratory tests in the last week meet the following conditions: Neutrophil (ANC) =1.5×10^9/L; Platelet (PLT) = 80×10^9/L, hemoglobin (Hb) = 80g/L; Total bilirubin (TBI) =1.5×upper limit of normal (2mg/dl); Alanine aminotransferase (ALT), aspartate aminotransferase (AST) = 2 × upper limit of normal; Creatinine (Cr) = 1.5 × upper limit of normal; Coagulation parameters (INR and PTI in the normal range); 5. Patients volunteered and signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Severe cardiovascular and cerebrovascular diseases, diabetes, organ dysfunction and recent history of myocardial infarction (3 months); 2. HIV infection, viral hepatitis; 3. Acute infection, and severe infection uncontrolled or fever patients; 4. Pregnant or lactating women; 5. Severe autoimmune disease patients; 6. Patients who are using immunosuppressive drugs or long-term immunosuppressants after organ transplantation; 7. T-cell lymphoma patients; 8. Allergies, especially those with IL-2 allergies; 9. Serious liver and kidney dysfunction; 10. Serious coagulation disorders; 11. Stubborn or persistent epilepsy; 12. Mental illness and severe depression; 13. Researchers think it is not suitable for enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Tumor lesions assessment;lymphocyte subsets;tumor markers test; | — |
Secondary
| Measure | Time frame |
|---|---|
| blood tests, urine tests, blood biochemistry;KPS;ECOG score;short-term efficacy; | — |
Countries
China
Contacts
Public ContactYu-min Li
Lanzhou University
Outcome results
None listed