Locally advanced nasopharyngeal carcinoma
Conditions
Interventions
Test group:S-1
Sponsors
Jiangsu Provincial Cancer Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-65 years old; 2. pathologically diagnosed as differentiated and undifferentiated type of non-angular Huafing nasopharyngeal carcinoma; 3. Clinical staging is T3-4N0-2M0, T1-4N2-3M0 (except T3N0 according to the 7th edition UICC staging Standard), a first-line scheme has been adopted (TP/TPF/ PF) induction or synchronous chemotherapy in 2-4 weeks, the curative effect of radical radiotherapy at the end of the treatment was CR/PR/SD; 4. Baseline laboratory tests meet the following criteria: Bone marrow function: WBC=4.0x10^9/L,ANC=2.0x10^9/L,PLT=100x10^9/L, Hb=90g/L; Liver function: Total bilirubin =ULN,AST, ALT=ULNx2.5, alkaline phosphatase =ULNx5, Kidney function: serum creatinine (Cr) =ULN and ccr=60 ml/min (using Cockcroft-gault formula); Cardiac function: ECG is basically normal; 5. Expected survival time = 12 months; 6. KPS score =70; 7. Patients or their legal representatives voluntarily sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with PD at the end of radiotherapy; 2. Patients who used targeted drugs 3. Patients who have been treated with a non-front-line regimen 4. Known to be allergic to S-1 5. Malignant neoplasm of other histological sources other than nasopharyngeal malignancies 6. Pregnant, lactating women 7. Any serious complication
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| No disease progression survival;No recurrence survival rate of lymph nodes ;No distant metastasis survival period;Overall survival; | — |
Countries
China
Contacts
Public ContactXia He
Jiangsu Provincial Cancer Hospital
Outcome results
None listed