primary Sjogren's syndrome
Conditions
Interventions
Case series:None
Sponsors
First Affiliated Hospital of Kunming Medical University
Eligibility
Sex/Gender
All
Age
30 Years to 70 Years
Inclusion criteria
Inclusion criteria: Patients with all of the following conditions will be considered for conclusion: Meeting at least two of the following items: 1. Serum anti-Sjogren syndrome A (anti-SSA)- and/or anti-SSB-positive, or rheumatoid factor positive with serum antinuclear antibody = 1:320; 2. Ocular staining score (OSS) =3; 3. Biopsy of the labial gland showed lymphocyte lesions =1/4 mm2 (at least 50 lymphocyte aggregates within 4mm2 tissue); (1) Presence of sensory, motor, autonomic dysfunction; (2) Aged 30-70 years male and female; (3) Provision of written informed consent.
Exclusion criteria
Exclusion criteria: Patients with one or more of the following conditions will be excluded from this study: 1. A history of external neck, head and face radiation therapy; 2. Sarcoidosis, amyloidosis, graft-versus-host disease, and IgG4-related diseases; 3. Bloodborne diseases; 4. Peripheral neuropathy caused by other diseases; 5. Endocrine disease or other connective tissue diseases; 6. Severe heart, liver, kidney insufficiency, alcoholism or mental illness; 7. Those receiving therapy for abnormal clotting factors and/or anticoagulant therapy; 8. Those present with swelling at the end of the limb; 9. Dermatitis; 10. Poor compliance or refusal to collaborate; 11. Those recently suffering from myocardial infarction; 12. Those taking immunosuppressant; 13. Those wearing a pacemaker or other implantable medical device; 14. Those highly allergic to stimulation; 15. Pregnant woman.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rate of abnormal motor nerve conduction velocity; | — |
Secondary
| Measure | Time frame |
|---|---|
| Rate of abnormal terminal motor latency;Rate of abnormal compound muscle action potential amplitude;Rate of sensory nerve conduction velocity;Rate of abnormal sensory nerve action potential amplitude;Rate of abnormal F wave;Rate of abnormal sympathetic skin response; | — |
Countries
China
Contacts
Public ContactDan Wang
First Affiliated Hospital of Kunming Medical University
Outcome results
None listed