Atherosclerosis
Conditions
Interventions
Exenatide group:Exenatide 10ugBid
Insulin group:Aspart 30 insulin
Sponsors
Beijing Hospital
Eligibility
Sex/Gender
All
Age
20 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Type 2 diabetes according to the diagnostic criteria, World Health Organization (WHO), 1999; 2. Aged between 20 and 75years; 3. Suboptimal glucose control with HbA1C between 7.5% and11%; 4. More than 2 OADs with more than the 1/2 maximum dose in at least last 3 months.
Exclusion criteria
Exclusion criteria: 1. Type 1 diabetes; 2. The stenosis of any segment of carotid artery more than 75% proven by high frequency B-ultrasound; An acute cardiovascular event within 30 days prior to randomization; 3. Currently planned coronary, carotid or peripheral artery revascularization or cardiac valve surgery; 4. Previous use of insulin or exenatide more than 1month; 5. Alanine aminotransferase (ALT) or aspartate aminotransferase (AST) level > 2.5 times the upper limit of normal; 6. Serum creatinine =133 µmol/L for male and =106 µmol/L for female; 7. Participating in or had completed another clinical trial of an investigational agent less than 3 months; 8. Positive urinary HCG test or Do not agree to use a reliable method of birth control during the study, as determined by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| carotid intima-media thickness(CIMT); | — |
Secondary
| Measure | Time frame |
|---|---|
| HbA1c;hs-CRP;fibrinogen;8-OHdG;blood pressure;weight; | — |
Countries
China
Contacts
Public ContactLixin Guo
Beijing Hospital
Outcome results
None listed