dense vitreous hemorrhage following various retinal disease
Conditions
Interventions
treatment group 1:intravitreal urokinase combined with triamcinolone acetonide
observation group:no interfere
treatment group 2:intravitreal injection of urokinase combined with conbercept
Sponsors
Xi'an 1st Hospital
Eligibility
Sex/Gender
All
Age
40 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. VH by dilated pupil examination with funduscopy, presenting with no main retinal vessels /only optic nerve head visible possible; 2. VH in a single eye for 2-4 weekswith low visual acuity no more than 0.2; 3. VH in phakic eyes; 4. Patients with or without previous focal or grid macular laser treatments; 5. Intraocular pressure (IOP) below 21 mmHg by the measurement with tonometry; 6. Patients who are for the first time confirmed as having VH and undergo relevant treatments; 7. Aged over 40 years; 8. Irrespective of genders; 9. Provision of signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with hemorrhages less than two weeks or more than four weeks from onset; 2. Patients with a specific allergy to any components of the relevant drugs; 3. Patients with a history of neuropathy or PPV surgery; 4. Patients with known coagulation dysfuntion or current use of anticoagulative medications other than aspirin; 5. Patients with uremia disease, a myocardial or cerebral vascular disease within one year duration, or hypertension with systolic pressure over 150 mmHg and/or diastolic pressure over 95 mmHg; 6. Patients with a history of diabetes mellitus, but fasting blood glucose is greater than 11.1mmol/l; 7. Patients with bilateral VHsignificant lens opacities, or diagnosis with any type of glaucoma; 8. Patients with a recent traumatic eye injury in the affected eye; 9. Concurrent retinal diseases detected by B-scan ultrasound at baseline, such as local vitreoretinal adhesion or traction, retinal detachment, or proliferation of the retina; and 10. Other VH after intraocular malignancy or no reason.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Best-corrected visual acuity;Degree of clearence of vitreous hemorrhage;intraocular pressure (IOP); | — |
Countries
China
Contacts
Public ContactPerlin Lv
Xi'an 1st Hospital
Outcome results
None listed