Dry eye
Conditions
Interventions
SSRI:SSRI treatment
control:Psychotherapy
Sponsors
The Eye & ENT Hospital of Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Voluntarily participated in this clinical study and signed an informed consent; 2. Male or female, aged 18 to 70 years old; 3. Patients diagnosed with mild depression; 4. Patients with dry eye signs and symptoms, consistent with either criterion as follows: (1) Criterion 1: Patients with at least one positive symptom, such as dry eye, foreign body sensation, burning sensation, eye fatigue,eye distension, vision fluctuation; And tear film break-up time equal to or less than 5 seconds, or Schirmer test (without anesthetic) equal to or less than 5 mm/5 minutes; (2) Criterion 2: Patients with at least one positive symptom, such as dry eye, foreign body sensation, burning sensation, eye fatigue, eye distension, vision fluctuation; And tear film break-up time equal to or less than 10 seconds and longer than 5 seconds, or Schirmer test (without anesthetic) equal to or less than 10 mm/5 minutes and longer than 5 mm/5 minutes; And patients should show positive corneal fluorescein staining; 5. welling to follow the requirements of this study; 6. Subjects did not participate in other clinical trials during the last four weeks; 7. Subjects did not use any medications other than SSRI
Exclusion criteria
Exclusion criteria: 1. Patients with moderate or severe depression; 2. Patients with severe primary disease such as severe heart, brain and blood vessels, liver, kidney and hematopoietic systems disease; 3. Patients who received intraocular surgery or with intraocular trauma in the last six months; 4. Pregnant women and menopause women; 5. Subjects did not use any topical medications other than artifical tears, or have used these medications, but withdrawed them more than two weeks before; 6. Patients who cannot obey the required treatments and follow-ups during the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Schirmer I test;Break-up Time;Ocular surface disease index (OSDI);cornea andconjunctiva stainning;MGD grading;anterior segment evaluation;Self-rating depression scale,SDS; | — |
Countries
China
Contacts
Public ContactGong Lan
The Eye & ENT Hospital of Fudan University
Outcome results
None listed