Idiopathic membranous nephropathy
Conditions
Interventions
1:TAC monotherapy
2:TAC plus steroid treatment
Sponsors
Renal Division, Department of Internal Medicine, Shanghai Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) Aged 18-80 years; 2) Renal biopsy proven IMN (Stage I-IV); 3) Proteinuria >4g/24hr or serum albumin100 RU/ml or eGFR decline =30% when IMN diagnosed within 6~12 months; 4) eGFR>30 ml/min/1.73m2; 5) Inform consent signed.
Exclusion criteria
Exclusion criteria: 1) Renal biopsy findingsinterstitial fibrosis >50%; 2) Infectious disease including uncontrolled hepatitis b, hepatitis c, tuberculosis, HIV; 3) Active GI ulcer within 3 months of randomization; 4) Untreated malignancy; 5) Received steroid or immunosuppressant within 3 months of screening; 6) ALTAST?total bilirubin more than 1.5 fold of normal range; 7) Critical conditions such as severe infection, MODS etc.; 8) Pregnancy or lactation; 9) Known allergic to intervention drugs; 10) Enrolled in other clinical studies within 3 months of randomization; 11) Unsuitable to be enrolled in the study judged by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 24hr proteinuria remission rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum PLA2R;24hr proteinuria level;serum albumin; | — |
Countries
China
Contacts
Public ContactGengru Jiang
Renal Division, Department of Internal Medicine, Shanghai Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine
Outcome results
None listed