Comparative Evaluation of Novel Strategies for Colorectal Cancer Screening in China: a Multicenter Randomized Controlled Trial (TARGET-C study)

Conditions

Colorectal Cancer

Hongda Chen, Jiahui Si, Chenyu Luo, Jianbo Tian, Junyi Xin et al. (21 authors)

Genome Medicine2026-03-19

Effectiveness and cost-effectiveness of risk-adapted colorectal cancer screening: a randomized controlled trial and modeling analysis.

Chen HD, Lu B, Shi JF, Zhou YY, Du LB, Liao XZ, Wei DH, Dong D, Gao Y, Zhu C, Ying RB, Zheng WF, Yan SP, Xiao HF, Zhang J, Kong YX, Li FR, Li N, Luo JH, Luo CY, Brenner H, Dai M.

2025-11-24

10.1186/s40779-025-00671-7

Gut microbiome mediates the associations between lifestyle factors and risk of colorectal high-risk adenoma: results from a population-based cohort study

Kai Song, Jiahui Luo, Yuhan Zhang, Dong Wu, Hongda Chen et al. (6 authors)

mSystems2025-09-22

10.1128/msystems.00933-25

Comparison of Colonoscopy, Fecal Immunochemical Test, and Risk-Adapted Approach in a Colorectal Cancer Screening Trial (TARGET-C).

Chen H, Shi J, Lu M, Li Y, Du L, Liao X, Wei D, Dong D, Gao Y, Zhu C, Ying R, Zheng W, Yan S, Xiao H, Zhang J, Kong Y, Li F, Zou S, Liu C, Wang H, Zhang Y, Lu B, Luo C, Cai J, Tian J, Miao X, Ding K, Brenner H, Dai M.

2022-08-1139 citations

10.1016/j.cgh.2022.08.003

Comparative Evaluation of Participation and Diagnostic Yield of Colonoscopy vs Fecal Immunochemical Test vs Risk-Adapted Screening in Colorectal Cancer Screening: Interim Analysis of a Multicenter Randomized Controlled Trial (TARGET-C)

Hongda Chen, Ming Lu, Cheng‐Cheng Liu, Shuangmei Zou, Lingbin Du et al. (32 authors)

The American Journal of Gastroenterology2020-04-1076 citations

10.14309/ajg.0000000000000624

Comparative evaluation of novel screening strategies for colorectal cancer screening in China (TARGET-C): a study protocol for a multicentre randomised controlled trial

Hongda Chen, Ni Li, Jufang Shi, Jiansong Ren, Chengcheng Liu et al. (9 authors)

BMJ Open2019-04-0129 citations

10.1136/bmjopen-2018-025935

Interventions

Colonoscopy group:One-time colonoscopy screening

FIT group:repeated fecal immunochemical test for 4 years

risk assessment+FIT group:Risk assessment is conducted for the participants at baseline: For thoese who are evaluate to be high-risk of colorectal cancer, colonoscopy is referred

For those who are evaluated to be low risk of colorectal cancer, FIT is provided and those who have positive FIT results, colonoscopy is referred.

Eligibility

Sex/Gender

All

Age

50 Years to 74 Years

Inclusion criteria

Inclusion criteria: 1. Habitant of the study region; 2. Aged 50-74 years old; 3. Able to provide informed consent.

Exclusion criteria

Exclusion criteria: 1. Prior history of colorectal cancer; 2. Prior history of colonic resection; 3. Undertaking any kind of cancer related therapy (Except for non-melanoma skin cancer); 4. Prior colonic examination, including colonoscopy, flexible sigmoidoscopy, CT colonograpy and Barium enema within five years; 5. Prior history of fecal occult blood test and fecal DNA test within 1 year; 6. Symptoms of lower gastrointestinal tract disease warranting colonoscopic evaluation, including: 1) More than one episode of rectal bleeding within the past 6 months; 2) Documented iron deficiency anemia; 3) Significant documented unintentional weight loss (>10% of baseline weight) over 6 months; 7. Significant comorbidity that would preclude benefit from screening or pose significant risk for the performance of colonoscopy (e.g. severe lung disease, end-stage renal disease, end-stage liver disease, severe heart failure, recent diagnosis of cancer (with the exception of non-melanoma skin cancer)).

Design outcomes

Primary

Measure	Time frame
Detection rate of advanced colorectal neoplasm (including colorectal cancer and advanced adenoma);	—

Secondary

Measure	Time frame
Mortality rate of colorectal cancer;Detection rate of any colorectal neoplasm;Compliance rate;Complication rate;	—

Countries

China

Contacts

Public ContactMin Dai

Cancer Hospital Chinese Academy of Medical Sciences

daimin2002@hotmail.com+86 10 87787428

Outcome results

None listed