Postoperative Delirium and Postoperative Cognitive Dysfunction
Conditions
Interventions
intranasal insuline group:intranasal insuline
Sponsors
The 3rd hospital of Xiangya
Eligibility
Sex/Gender
All
Age
60 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. aged>60 years, ASA?-III,patients will have elective operation, time of operation=2h; 2. Diagnosis of metabolic syndrome before operation; 3. Patient can assisting evaluating cognitive function; 4. Agree to participate in the study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. patient or family member's refusal and attitude unknown; 2. There is a central nervous system disease (such as AD,amyotrophic lateral sclerosis, mental disease,epilepsy,Parkinsons,intracranial tumours); 3. Drug abuse(such as sedative and/or antidepressant; 4. Severe hearing or visual impairment, end-stage disease can not communicate; 5. The attending physician or researcher believes there are other conditions that should not be included in this study(need record).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative delirium;Postoperative cognitive dysfunction; | — |
Secondary
| Measure | Time frame |
|---|---|
| oxidative stress and inflammation level;insuline resistance related indicators;Carotid artery blood vessels; | — |
Countries
China
Contacts
Public ContactOuyang Wen
Anesthesiology department, The Third Xiangya hospital of Central South University
Outcome results
None listed